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Im not sure either. My DD seemed very highly sensitive as a small child but she has kind of grown out of them or at least can cope in less than ideal settings now. However, my DS has not grown out of them and we are now awaiting his first assessment appt with the community paediatrician to see if he has Aspergers or something. Im not sure there is exactly a difference. I gather that many Aspergers people have a highly sensitive nervous system – thats a typical trait for them although obviously the converse is not true – having a highly sensitive nervous system does not necessarily mean you have Aspergers. I think its your reaction to your sensitivity which may show the difference, if you see what I mean??